Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

27.7K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
27.7K
DNA as a Genetic Template02:05

DNA as a Genetic Template

9.5K
9.5K
Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents01:13

Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents

6.0K
Carboxylic acids can be prepared by the carboxylation of Grignard reagents (RMgX). This method is convenient for converting alkyl (primary, secondary or tertiary), vinyl, benzyl, and aryl halides to carboxylic acids with one additional carbon than the starting RMgX.
6.0K
Acidity of Carboxylic Acids01:21

Acidity of Carboxylic Acids

8.7K
Carboxylic acids are the strongest organic acids. However, their acidic strength is much less than mineral acids like HCl. Carboxylic acids ionize in water and readily lose the hydroxyl proton to form a resonance-stabilized carboxylate ion.
8.7K
Carboxylic Acids to Acid Chlorides01:18

Carboxylic Acids to Acid Chlorides

8.8K
Carboxylic acids react with SOCl2 or PCl5 to form acid chlorides. Amongst the carboxylic acid derivatives, acid chlorides are the most reactive and synthetically important derivatives. They are useful reagents for Friedel–Crafts acylation of some aromatic compounds.
8.8K
Carboxylic Acid Derivatives: Overview01:15

Carboxylic Acid Derivatives: Overview

5.3K
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, characterization, and imidogen photochemistry of a hydrazoic acid adduct of Rh<sub>2</sub>.

Chemical science·2026
Same author

<i>In Crystallo</i> Synthesis of a Triplet Silver Nitrene.

Journal of the American Chemical Society·2026
Same author

Tandem mechanochemical engineering yields highly crystalline metal-organic frameworks.

Chemical science·2026
Same author

Monitoring the Stability of Porous Coordination Cages during the Photoreduction of Porous Salt Thin Films.

Inorganic chemistry·2026
Same author

Multisite Proton-Coupled Electron Transfer Enables Iodanyl Radical Catalysis.

Journal of the American Chemical Society·2025
Same author

Synthesis and Application of Bioactive N-Functionalized Aziridines.

Angewandte Chemie (International ed. in English)·2025
Same journal

From cyclic diaryl λ<sup>3</sup>-bromanes/chloranes to polyfuntionalized biarylsilanes <i>via</i> aryne σ-bonds.

Chemical science·2026
Same journal

Non-equilibrium formation of the elusive dibridged diboranyl (B<sub>2</sub>H<sub>5</sub>) radical and boranes in low-temperature diborane ices.

Chemical science·2026
Same journal

Visible-light-driven ruthenium-catalyzed hydrogenation of manganese nitride complexes to ammonia under ambient conditions.

Chemical science·2026
Same journal

Quantification of mesopore infiltration in a polymer-grafted metal-organic framework.

Chemical science·2026
Same journal

Enhanced and selective oxygen reduction by iron porphyrin with a biguanide residue in the second coordination sphere.

Chemical science·2026
Same journal

Excited-state orbital angular momentum enables all-optical molecular spin coherence.

Chemical science·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique
12:43

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique

Published on: November 28, 2016

9.1K

Templating metastable Pd2 carboxylate aggregates.

Chen-Hao Wang1, Wen-Yang Gao1, Qing Ma2

  • 1Texas A&M University , Department of Chemistry , College Station , TX 77843 , USA .

Chemical Science
|March 8, 2019
PubMed
Summary
This summary is machine-generated.

This study demonstrates a new method using metal-organic frameworks (MOFs) to create specific, metastable palladium-2 (Pd2) aggregates for catalysis. This approach overcomes challenges in synthesizing these crucial polynuclear metal sites, which are typically unavailable in solution.

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.1K
Particle Templated Emulsification enables Microfluidic-Free Droplet Assays
11:03

Particle Templated Emulsification enables Microfluidic-Free Droplet Assays

Published on: March 9, 2021

6.7K

Related Experiment Videos

Last Updated: Jan 28, 2026

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique
12:43

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique

Published on: November 28, 2016

9.1K
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.1K
Particle Templated Emulsification enables Microfluidic-Free Droplet Assays
11:03

Particle Templated Emulsification enables Microfluidic-Free Droplet Assays

Published on: March 9, 2021

6.7K

Area of Science:

  • Inorganic Chemistry
  • Materials Science
  • Catalysis

Background:

  • Metal-metal (M-M) cooperation in catalysis relies on specific polynuclear metal aggregates with defined geometry and size.
  • Synthesizing such aggregates, particularly palladium-2 (Pd2) carboxylates with close Pd-Pd interactions, is challenging due to thermodynamic instability in solution.
  • Existing methods often yield palladium-3 (Pd3) trimers (Pd3(OAc)6) lacking the desired M-M proximity.

Purpose of the Study:

  • To develop a synthetic strategy for accessing metastable Pd2 aggregates.
  • To utilize ion metathesis within pre-formed metal-organic frameworks (MOFs) as a templating method.
  • To create specific Pd2 tetracarboxylate sites inaccessible through conventional solution-phase chemistry.

Main Methods:

  • Ion metathesis reactions performed within the pores of pre-formed metal-organic frameworks (MOFs).
  • Characterization of the synthesized materials using techniques including elemental analysis, Powder X-ray Diffraction (PXRD), Single-Crystal X-ray Diffraction (SCXRD), Extended X-ray Absorption Fine Structure (EXAFS), X-ray Absorption Near Edge Structure (XANES), and gas adsorption analysis.
  • Investigation of network solvation effects on reaction kinetics using coupled Thermogravimetric Analysis-Mass Spectrometry (TGA-MS) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

Main Results:

  • Successful synthesis of metastable Pd2 tetracarboxylate sites within MOFs via templated ion metathesis.
  • Comprehensive structural and electronic characterization confirming the formation of the desired Pd2 aggregates.
  • Identification of network solvation as a critical factor influencing the kinetics of the ion metathesis process.

Conclusions:

  • Templated ion metathesis within MOFs provides a viable route to generate specific, metastable polynuclear metal aggregates.
  • This MOF-based approach overcomes the limitations of solution-phase synthesis for accessing catalytically relevant Pd2 sites.
  • The methodology opens new avenues for studying the chemistry and catalytic potential of precisely engineered metal aggregates.