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[2-Arylidene 3,4-dihydro-1 (2H)-naphthalenones with potential platelet anti-aggregating activity: synthesis and
Il Farmaco; Edizione Scientifica
|February 1, 1986
Abstract:
New 3,4-dihydro-2-arylidene-1-(2H)-naphthalenones derivatives were synthesized and their inhibitory effects in vitro on the arachidonic acid-induced platelet aggregation were evaluated. The 3,4-dihydro-2-[(2,5-dimethoxyphenyl)methylene]-1-(2H)-naphthalenone++ + exhibits the most potent antiaggregating activity; compared with aspirin this compound is three times more active. Its crystal structure has been determined.