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Lactobacillus endocarditis.

A J Davies, P A James, P M Hawkey

    The Journal of Infection
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Two cases of endocarditis caused by Lactobacillus bacteria were successfully treated medically. Penicillin-tolerant Lactobacillus casei var. rhamnosus highlights the need for combination therapy in treating Lactobacillus endocarditis.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Cardiology

    Background:

    • Endocarditis is a serious infection of the heart's inner lining, often caused by bacteria.
    • Lactobacillus species, typically considered commensal, can rarely cause severe infections like endocarditis.

    Observation:

    • This study describes two cases of endocarditis caused by Lactobacillus plantarum and Lactobacillus casei var. rhamnosus.
    • Both patients received successful medical treatment for their infections.

    Findings:

    • Lactobacillus isolates were tested for their response to penicillin using continuous growth monitoring.
    • A strain of Lactobacillus casei var. rhamnosus exhibited penicillin tolerance.
    • This finding suggests that standard penicillin monotherapy may be insufficient for certain Lactobacillus strains.

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    Implications:

    • The study discusses using a combination of penicillin and gentamicin for endocarditis caused by penicillin-tolerant Lactobacillus strains.
    • It also assesses criteria for selecting appropriate oral agents to complete treatment after intravenous therapy.
    • This research informs clinical decisions for managing rare but serious Lactobacillus endocarditis cases.