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Primary structural repeats in human and in murine gamma-interferon
Journal of Interferon Research
|February 1, 1986
Summary
The Sellers TT algorithm identified two major repeats in human and murine gamma-interferon amino acid sequences. These repeats divide the proteins into distinct amino- and carboxyterminal segments, revealing structural patterns.
Area of Science:
- Biochemistry
- Molecular Biology
- Genomics
Background:
- Human and murine gamma-interferon are crucial immune proteins.
- Understanding protein structure is key to function.
- Previous analyses may not have fully resolved repeating elements.
Purpose of the Study:
- To investigate the primary amino acid sequence of gamma-interferon.
- To identify and characterize repeating patterns within the sequence.
- To delineate structural segments of the protein.
Main Methods:
- Application of the Sellers TT algorithm for pattern searching.
- Detailed analysis of the amino acid sequences of human and murine gamma-interferon.
- Comparative sequence analysis.
Main Results:
- Identification of two significant large repeats in both human and murine gamma-interferon.
- These repeats partition the protein sequences.
- Defined aminoterminal and carboxyterminal segments were observed.
Conclusions:
- The Sellers TT algorithm effectively revealed conserved structural motifs in gamma-interferon.
- The identified repeats suggest functional or evolutionary significance.
- The sequence segmentation provides a basis for further structural and functional studies.