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Pain affect disrupted in children with posterior cerebellar tumor resection

Katie E Silva1, Julie Rosner1, Nicole J Ullrich2,3,4

  • 1Center for Pain and the Brain Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts 02215.

Annals of Clinical and Translational Neurology
|March 9, 2019
PubMed

Insights

Pediatric patients with posterior cerebellar tumors showed reduced pain tolerance and altered brain responses to pain. Surgical removal may increase risks for developing pain disorders.

Area of Science:

  • Neuroscience
  • Pediatric Oncology
  • Pain Research

Background:

  • Posterior cerebellum damage is linked to affective deficits and altered pain modulation.
  • Cerebellar infarcts in adults can cause thermal hyperalgesia and affect pain modulation.

Purpose of the Study:

  • To evaluate the impact of low-grade cerebellar tumor resection on pain processing in children.
  • To investigate how surgery for posterior cerebellar tumors affects pain perception and brain activity.

Main Methods:

  • Quantitative sensory testing and functional magnetic resonance imaging (fMRI) were used.
  • Pediatric patients with posterior cerebellar gliomas (Crus Patients) were compared to matched controls.
  • Pain tolerance, detection, and pain thresholds were assessed, alongside fMRI responses to thermal stimuli.

Main Results:

  • Crus Patients exhibited significantly lower pain tolerance to cold stimuli compared to controls.
  • No significant differences were found in heat and cold detection or pain thresholds.
  • Patients showed decreased fMRI responses in the anterior insula to painful heat stimuli.

Conclusions:

  • Posterior cerebellar hemisphere damage disrupts affective pain processing and endogenous pain modulation.
  • Surgical resection in this region may heighten the risk of developing pain disorders in children.
  • Findings highlight the cerebellum's role in affective pain processing and pain modulation.
Abstract

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