Histodifferentiation and ultrastructure of oral squamous cell carcinoma in HMT rats

Seven oral squamous cell carcinomas developed in HMT rats were studied with light and electron microscopy. Two carcinomas in extra-oral sites were also described. Histodifferentiation of oral squamous cell carcinomas ranged from well-differentiated to poorly-differentiated, comparable to that of the same disease in humans. Ultrastructural features characteristic of human oral carcinomas were observed in the HMT rat carcinomas.