Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis
Heather L Teague1, Nevin J Varghese1, Lam C Tsoi2
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Abstract:
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.
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