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Updated: Jan 28, 2026

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals
Published on: May 25, 2016
Regio- and Chemoselective Deprotection of Primary Acetates by Zirconium Hydrides
Marine Gavel1, Thibaut Courant1, Antoine Yvan Philippe Joosten1
1Normandie Univ , INSA Rouen, UNIROUEN, CNRS, COBRA UMR 6014 , 76000 Rouen , France.
Abstract:
A combination of DIBAL-H and Cp2ZrCl2 is shown to promote the regioselective cleavage of primary acetates on a broad scope of substrates, ranging from carbohydrates to terpene derivatives, with a high tolerance toward protecting groups and numerous functionalities found in natural products and bioactive compounds. Apart from providing highly valuable building blocks in only two steps from biosourced raw materials, this selective de- O-acetylation should also be strongly helpful to solve selectivity issues in organic synthesis.
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