Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.5K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.5K
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

1.6K
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
1.6K
Colors and Magnetism03:02

Colors and Magnetism

14.0K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.0K
Color Vision01:24

Color Vision

1.5K
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
1.5K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

465
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
465
Skin Cancer01:30

Skin Cancer

5.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Missing Conversation in Burn Care: Intimacy & Sexuality.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

The need for dried plasma-Still a national issue: Where are we and recommendations.

Transfusion·2026
Same author

Ultra-Early Mobilization After Split-Thickness Skin Grafting in Burn Patients Is Not Associated with Graft Loss.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Laser-Assisted Drug Delivery of 5-Fluorouracil and Triamcinolone vs. Triamcinolone Monotherapy Does Not Lead to Different Outcomes in the Treatment of Burn Hypertrophic Scars.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial.

JAMA·2026
Same author

AGE AS A DETERMINANT: INVESTIGATING THE EFFICACY OF LASER TREATMENT OUTCOMES FOR BURN HYPERTROPHIC SCAR ACROSS AGE COHORTS.

Journal of burn care & research : official publication of the American Burn Association·2026

Related Experiment Video

Updated: Jan 28, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

2.2K

Dyspigmented hypertrophic scars: Beyond skin color.

Abdulnaser Alkhalil1, Bonnie C Carney1,2, Taryn E Travis1,3

  • 1Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia.

Pigment Cell & Melanoma Research
|March 9, 2019
PubMed
Summary

Investigating scar pigmentation differences revealed distinct gene expression patterns. Hypopigmented scars showed inflammatory and metabolic pathway activity, while hyperpigmented scars involved stem cell development, offering potential therapeutic targets for wound healing.

Keywords:
dyspigmentationred Durocscartranscriptomewound

More Related Videos

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

7.1K
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Related Experiment Videos

Last Updated: Jan 28, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

2.2K
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

7.1K
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Area of Science:

  • Wound healing and tissue regeneration
  • Dermatology and skin biology
  • Genomics and molecular biology

Background:

  • Mechanisms of dyspigmentation after skin injury remain unclear.
  • Understanding gene transcription differences in scar tissue is crucial for therapeutic development.
  • Current knowledge focuses on pigment synthesis, not post-injury dyspigmentation.

Purpose of the Study:

  • To investigate genomic transcription differences in hyper- and hypopigmented scar tissue.
  • To identify molecular pathways associated with scar dyspigmentation.
  • To discover potential therapeutic gene targets for treating abnormal scar pigmentation.

Main Methods:

  • Utilized a red Duroc swine scar model to compare injured and uninjured skin.
  • Analyzed genomic transcription profiles of hyper- and hypopigmented scar tissues.
  • Performed Ingenuity Pathway Analysis (IPA) on significantly modulated genes.

Main Results:

  • Transcription profiles differed significantly between hyper- and hypopigmented scars.
  • Hypopigmented scars showed enrichment in redox, metabolic, and inflammatory pathways.
  • Hyperpigmented scars were associated with stem cell development and differentiation pathways.
  • Predicted active pathways in hyperpigmented scars included cell-cell interactions and inflammation.
  • Predicted inactive pathways in hypopigmented scars included inflammation and high-mobility group box 1.
  • Differentially regulated genes highlighted metabolic, inflammatory, and oxidative stress pathways in hypopigmented scars.
  • Melanin synthesis, glycosaminoglycans biosynthesis, and cell differentiation pathways were predominant in hyperpigmented scars.

Conclusions:

  • Scar pigmentation phenotypes are associated with distinct genomic transcription profiles.
  • Specific molecular pathways are implicated in hyper- and hypopigmented scar formation.
  • Identified potential therapeutic gene targets for managing dyspigmentation in scar tissue.