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Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory

Meenu Mehta1, Deeksha1, Neha Sharma1

  • 1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara, 144411, Punjab, India.

Chemico-Biological Interactions
|March 9, 2019
PubMed

Insights

Novel drug delivery systems (NDDS) effectively target macrophages for treating inflammatory respiratory diseases. These systems enhance drug efficacy, reduce toxicity, and improve patient outcomes by targeting alveolar macrophages.

Area of Science:

  • Immunology
  • Pharmacology
  • Biotechnology

Background:

  • Macrophages are crucial hematopoietic cells involved in tissue homeostasis, immunity, and pathogenesis.
  • Their role in inflammatory respiratory diseases makes them a key therapeutic target.
  • Current treatments can be limited by toxicity and efficacy issues.

Purpose of the Study:

  • To review novel drug delivery systems (NDDS) for targeting macrophages in respiratory diseases.
  • To explore how NDDS properties influence macrophage uptake and therapeutic outcomes.
  • To discuss advancements in targeted and molecularly modified NDDS.

Main Methods:

  • Literature review of NDDS including nanoparticles, liposomes, and dendrimers.
  • Analysis of physiochemical properties and functional moieties for macrophage targeting.
  • Examination of modified NDDS for enhanced specificity and molecular targeting.

Main Results:

  • NDDS demonstrate enhanced targeting and uptake by alveolar macrophages.
  • Physiochemical properties and functional groups are critical for effective delivery.
  • Modified NDDS offer improved specificity and potential for molecular targeting.

Conclusions:

  • NDDS represent a promising strategy for treating inflammatory respiratory diseases by targeting macrophages.
  • These systems offer sustained drug delivery, reduced dosage, and lower toxicity.
  • Further development of modified NDDS holds potential for precise therapeutic interventions.
Keywords:
Antimicrobial peptidesAsthmaInflammationMacrophagesNanoparticlesNovel drug delivery systemsRespiratory diseases

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