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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

6.3K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Ecological Niches02:02

Ecological Niches

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All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
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Adult Stem Cells01:33

Adult Stem Cells

33.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.8K
Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Jan 28, 2026

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
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The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

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Stem Cell Aging? Blame It on the Niche.

Christopher S Morrow1, Darcie L Moore1

  • 1Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.

Cell Stem Cell
|March 9, 2019
PubMed
Summary

Aged neural stem cells struggle to activate due to niche-induced inflammation and Wnt signaling changes. These factors create barriers to exiting quiescence, impacting adult neurogenesis.

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Aging Research

Background:

  • Understanding the transition of neural stem cells from a quiescent to an active state is crucial for adult neurogenesis.
  • The aging process significantly impacts the stem cell niche and its regulatory functions.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying the impaired activation of aged neural stem cells.
  • To identify the role of the stem cell niche in hindering the exit from quiescence in aging.

Main Methods:

  • Analysis of aged neural stem cells and their surrounding niche environment.
  • Investigation of inflammatory signaling pathways within the niche.
  • Assessment of Wnt signaling pathway alterations in aged stem cells.

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Extended Live Imaging of Female Drosophila melanogaster Germline Stem Cell Niches
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Extended Live Imaging of Female Drosophila melanogaster Germline Stem Cell Niches

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Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
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Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

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Related Experiment Videos

Last Updated: Jan 28, 2026

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
09:38

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells

Published on: November 20, 2017

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Extended Live Imaging of Female Drosophila melanogaster Germline Stem Cell Niches
07:10

Extended Live Imaging of Female Drosophila melanogaster Germline Stem Cell Niches

Published on: December 20, 2024

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Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
10:11

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

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Main Results:

  • Aged neural stem cells exhibit increased resistance to exiting quiescence compared to younger cells.
  • The stem cell niche in aged individuals promotes inflammation.
  • Altered Wnt signaling in the niche contributes to the inhibition of neural stem cell activation.

Conclusions:

  • The aging stem cell niche imposes significant barriers to neural stem cell activation through inflammation and aberrant Wnt signaling.
  • These findings highlight the critical role of the niche microenvironment in regulating adult neurogenesis during aging.