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Plant components can reduce methylmercury toxication: A mini-review
Jie Chang1, Yun Zhou1, Qiang Wang1
1Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Biochimica Et Biophysica Acta. General Subjects
|March 9, 2019
Summary
Natural plant extracts show promise in reducing methylmercury (MeHg) toxicity. These extracts may offer new therapeutic strategies by blocking absorption and enhancing excretion of this neurotoxicant.
Area of Science:
- Environmental toxicology
- Neuroscience
- Pharmacology
Background:
- Methylmercury (MeHg) is a widespread neurotoxicant with incompletely understood mechanisms of action.
- Current therapeutic and preventive options for MeHg toxicity are limited.
- Emerging research indicates natural plant extracts may mitigate MeHg's adverse effects.
Purpose of the Study:
- To review effective natural plant extracts for mitigating methylmercury toxicity.
- To explore the biochemical mechanisms by which plant extracts reduce MeHg's harmful impacts.
Main Methods:
- Literature review of studies on natural plant extracts and methylmercury toxicity.
- Analysis of proposed biochemical pathways for MeHg detoxification by plant components.
Main Results:
- Natural plant extracts demonstrate potential as therapeutics against MeHg exposure.
- Plant-derived compounds can attenuate neurobehavioral deficits caused by MeHg.
- Mechanisms include reduced MeHg absorption, enhanced excretion, and restoration of cellular redox balance.
Conclusions:
- Natural plant components offer multifaceted protective effects against MeHg toxicity.
- Understanding these protective roles aids in elucidating MeHg neurotoxicity mechanisms.
- Plant extracts represent a promising avenue for developing novel therapeutic strategies for MeHg poisoning.
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