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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
891
The relation between PI3K/AKT signalling pathway and cancer
Saeed Noorolyai1, Neda Shajari1, Elham Baghbani1
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Gene
|March 9, 2019
Summary
Phosphatidylinositol 3-kinases (PI3K) pathway hyperactivation drives human cancers. This review examines PI3K family members and PI3K-Akt signaling mechanisms, offering insights for targeted cancer therapy development.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Phosphatidylinositol 3-kinases (PI3Ks) are key regulators of intracellular signaling pathways.
- Hyperactivation of PI3K signaling cascades is frequently observed in human cancers, presenting therapeutic challenges and opportunities.
Purpose of the Study:
- To review the phosphoinositide 3-kinases family.
- To explore the mechanisms of PI3K-Akt pathway stimulation in the context of cancer.
Main Methods:
- Literature review of PI3K pathway alterations in cancer.
- Analysis of oncogenic mechanisms involving PI3K, AKT, and PTEN.
Main Results:
- PI3K pathway dysregulation is common in cancer.
- Key components like receptor tyrosine kinases, PI3K's p110a subunit, AKT, and PTEN are frequently altered.
Conclusions:
- Understanding PI3K pathway mechanisms is crucial for developing effective cancer therapies.
- Targeting PI3K inhibitors represents a significant area of research in oncology.
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