Related Experiment Video

Updated: Jan 28, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

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The relation between PI3K/AKT signalling pathway and cancer

Saeed Noorolyai1, Neda Shajari1, Elham Baghbani1

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Gene
|March 9, 2019
PubMed

Insights

Phosphatidylinositol 3-kinases (PI3K) pathway hyperactivation drives human cancers. This review examines PI3K family members and PI3K-Akt signaling mechanisms, offering insights for targeted cancer therapy development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Phosphatidylinositol 3-kinases (PI3Ks) are key regulators of intracellular signaling pathways.
  • Hyperactivation of PI3K signaling cascades is frequently observed in human cancers, presenting therapeutic challenges and opportunities.

Purpose of the Study:

  • To review the phosphoinositide 3-kinases family.
  • To explore the mechanisms of PI3K-Akt pathway stimulation in the context of cancer.

Main Methods:

  • Literature review of PI3K pathway alterations in cancer.
  • Analysis of oncogenic mechanisms involving PI3K, AKT, and PTEN.

Main Results:

  • PI3K pathway dysregulation is common in cancer.
  • Key components like receptor tyrosine kinases, PI3K's p110a subunit, AKT, and PTEN are frequently altered.

Conclusions:

  • Understanding PI3K pathway mechanisms is crucial for developing effective cancer therapies.
  • Targeting PI3K inhibitors represents a significant area of research in oncology.
Keywords:
CancerPI3KsPTENSignalling pathway

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