Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conformity01:20

Conformity

48.1K
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
48.1K
Conformations of Butane02:20

Conformations of Butane

17.9K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
17.9K
DNA Helicases00:55

DNA Helicases

24.1K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.1K
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

14.4K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
14.4K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

15.5K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
15.5K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

18.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrical impedance spectroscopy of young and old mouse multiple tissues.

Biomedical physics & engineering express·2026
Same author

Late Preschool BMI Acceleration as the Strongest Predictor of Childhood Cardiometabolic Risk at School Entry: A Dual-Trajectory Cohort Study.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same author

Machine learning model for predicting rebleeding risk after endoscopic variceal ligation in esophageal variceal bleeding.

Scientific reports·2026
Same author

Cloning and functional determination of PpyASR1 during fruit development in Pyrus pyrifolia.

BMC plant biology·2026
Same author

Association Between Neutrophil Percentage to Albumin Ratio and Disease Activity in Hospitalized Patients with Rheumatoid Arthritis: A Cross-Sectional Study.

Journal of inflammation research·2026
Same author

Trojan horse-inspired smart single-atom nanozyme delivery system for synergistic therapy of inflammatory bowel disease.

Acta pharmaceutica Sinica. B·2026
Same journal

AI-driven photophysics-aware design of fluorescent probes with applications in α-synuclein biosensing and inhibitor screening.

Biosensors & bioelectronics·2026
Same journal

Three-dimensional helical integration of high-density linear microelectrode arrays and their cross-tissue applications.

Biosensors & bioelectronics·2026
Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026
Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026
Same journal

Rationally architected MOF-derived Co<sub>3</sub>O<sub>4</sub>@NiMn-LDH hollow heterostructure-based sensor array empowering sensitive detection and discrimination of neurological biomarkers.

Biosensors & bioelectronics·2026
Same journal

Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection.

Biosensors & bioelectronics·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K

DNA conformational polymorphism for biosensing applications.

Ziheng Hu1, Zhiguang Suo1, Wenxia Liu2

  • 1Materials Genome Institute, Shanghai University, 200444 Shanghai, China.

Biosensors & Bioelectronics
|March 9, 2019
PubMed
Summary
This summary is machine-generated.

DNA conformational polymorphism, including aptamers and DNAzymes, is rapidly advancing biosensing. This review covers DNA structures in electrochemical and fluorescent sensors for enhanced detection capabilities.

More Related Videos

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K
Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.7K

Related Experiment Videos

Last Updated: Jan 28, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K
Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.7K

Area of Science:

  • Biomolecular Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • DNA's unique structural diversity (duplex, triplex, quadruplex, origami) is increasingly utilized in biosensor design.
  • Functionalized DNA molecules like aptamers and DNAzymes offer specific molecular recognition capabilities.
  • DNA's role extends beyond recognition to signal reporting and structural scaffolding in biosensors.

Purpose of the Study:

  • To review the recent advancements in DNA conformational polymorphism for biosensing applications.
  • To highlight the integration of diverse DNA structures in electrochemical and fluorescent sensor development.
  • To provide insights into the future trajectory of DNA-based biosensors.

Main Methods:

  • Summarizing recent developments in DNA-based electrochemical sensors (amperometric, impedance, electrochemiluminescence, field-effect transistor).
  • Reviewing advancements in DNA-based fluorescent sensors, focusing on DNA's role in signal transduction and probe modification.
  • Analyzing the application of various DNA conformations (duplex, triplex, quadruplex, origami, aptamers, DNAzymes) in sensor construction.

Main Results:

  • DNA conformational polymorphism offers versatile platforms for constructing highly sensitive and specific biosensors.
  • Electrochemical and fluorescent sensing modalities have significantly benefited from the incorporation of diverse DNA structures.
  • Functionalized DNA elements act as crucial recognition receptors, signal reporters, and structural components.

Conclusions:

  • DNA conformational polymorphism is a rapidly evolving field with immense potential in biosensing.
  • Continued innovation in DNA structure engineering will drive the development of next-generation biosensors.
  • Future research should focus on integrating novel DNA structures and advanced signal transduction mechanisms for improved performance.