Related Experiment Video
Updated: May 26, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Trojan horse-inspired smart single-atom nanozyme delivery system for synergistic therapy of inflammatory bowel
Tianliang Li1, Zhijie Wang2, Xin Chang3
1Materials Genome Institute, Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials, and Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China.
Abstract:
Systemic administration for the clinical management of inflammatory bowel disease (IBD) often leads to various side effects and toxicities, primarily due to broad therapeutic exposure of non-target tissues. Herein, a smart single-atom nanozyme (SAzymes) delivery system (Fe-SA/Cur@HAD, FCH) is constructed through coordinating iron-doped SAzymes (Fe-SA) with curcumin (Cur) for IBD synergistic therapy. Inspired by Trojan horse, FCH efficiently responds to the IBD pathological microenvironment and realizes targeted delivery via oral administration. In inflamed colonic tissue, FCH regulates redox homeostasis through the superoxide dismutase (SOD)-catalase (CAT) cascade reaction and releases Cur by changing the adsorption energy, thus achieving synergistic therapy. An in vitro IBD model of human-derived colonic organoid, along with in vivo IBD model of mouse, were used and demonstrated that this system could effectively reduce reactive oxygen species (ROS) levels, improve intestinal homeostasis, and promote tissue recovery. Additionally, FCH markedly suppresses the activation of inflammatory pathways and modulates the composition of the intestinal microbiota. This study innovatively modifies SAzymes, offering new perspectives on their potential applications in IBD treatment.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease I: Introduction
Inflammatory Bowel Disease II: Ulcerative Colitis
Drugs for Treatment of Ulcerative Colitis in IBD

