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Automating Citrus Budwood Processing for Downstream Pathogen Detection Through Instrument Engineering

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Published on: April 21, 2023

Microbial engineering for easy downstream processing.

Ying Wang¹, Chen Ling², Yong Chen²

¹Department of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Biotechnology Advances

|March 10, 2019

Summary

This summary is machine-generated.

Morphologically engineering microbial cells simplifies downstream processing. Modified cells aggregate or enlarge for easier separation, reducing costs and improving efficiency in fermentation.

Keywords:

Cell lysis Cell wall engineering Downstream processing Microbial fermentation Morphology engineering PHB Synthetic biology

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Area of Science:

Biotechnology
Microbial Engineering

Background:

Downstream processing in microbial fermentation is costly and complex.
Current methods require specialized equipment for separating intracellular and extracellular products.

Purpose of the Study:

To simplify microbial cell separation in downstream processing.
To reduce the economic burden of fermentation by enabling easier product recovery.

Main Methods:

Morphological engineering of microbial cells to induce aggregation or enlargement (fibers, spheres).
Genetic manipulation of genes controlling microbial morphology.
Introduction of lysis genes for controlled cell disruption.

Main Results:

Engineered cells facilitate separation via gravity sedimentation or press filtration.
Co-production of intracellular and extracellular products becomes economically viable.
Potential for simplified and cost-effective downstream operations.

Conclusions:

Morphological engineering offers a promising strategy to streamline downstream processing.
This approach can significantly reduce costs and enhance efficiency in microbial fermentation.
Future developments are expected to lead to readily achievable cell separation.