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Published on: December 2, 2013
Design of bio-inspired adhesive surface composed of hexanoyl group-modified gelatin and silicon nanowire
Xi Chen1, Ryo Mizuta1, Naoki Fukata2
1Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan; Polymeric Biomaterials Group, Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Abstract:
To fabricate a soft-tissue adhesion surface by nanostructural control and functional modification, we prepared bio-inspired adhesive surfaces composed of hexanoyl group-modified gelatin (HxGltn) and silicon nanowire (SiNW). We synthesized the HxGltn with different modification ratios of 27 mol% (27HxGltn), 37 mol% (37HxGltn), and 50 mol% (50HxGltn) and processed two different types of SiNW plates (800 pitch and 1500 pitch) with 1400 nm in height and 400 nm in diameter (800/1400 SiNW and 1500/1400 SiNW, respectively. To enhance the adhesion to the intestine surface, we covalently immobilized HxGltn on the surface of SiNW plates. A significant increase in bonding strength was not observed when Gltn-, 27HxGltn-immobilized 800/1400 SiNW, and Gltn-, 27HxGltn, 37HxGltn, 50HxGltn-immobilized 1500/1400 SiNW were used. Furthermore, 37HxGltn- and 50HxGltn-immobilized 800/1400 SiNW only showed 5-fold higher bonding strength to intestine tissue compared with other samples. These 37HxGltn- and 50HxGltn-immobilized 800/1400 SiNW surfaces had potential for the application of soft tissue adhesion.
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