Related Experiment Video
Updated: Jan 28, 2026
09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
22.2K
Rethinking the Relationship Between Spatiotemporal Gait Variables and Dementia: A Prospective Study
Takehiko Doi1, Kota Tsutsumimoto2, Sho Nakakubo1
1Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan.
Journal of the American Medical Directors Association
|March 11, 2019
Summary
Quantitative gait analysis, including gait speed, stride length, and stride length variability, can predict the risk of developing dementia in older adults. These findings highlight gait function as a valuable tool for dementia risk assessment.
Area of Science:
- Neurology
- Gerontology
- Biomechanical Engineering
Background:
- The relationship between specific gait variables and the risk of developing dementia remains unclear.
- Identifying predictive markers for dementia is crucial for early intervention and management in aging populations.
Purpose of the Study:
- To investigate whether quantitative gait variables can predict the incidence of dementia in older adults.
- To establish cut-off values for gait parameters associated with dementia risk.
Main Methods:
- A prospective community-based study involving 4011 participants (mean age 72.2 years).
- Baseline measurements included gait speed, stride length, and stride length variability.
- Dementia incidence was tracked through medical records over a mean follow-up of 42.8 months.
Main Results:
- 245 incident cases of dementia were recorded during the follow-up period.
- Slow gait speed (HR 1.49), short stride length (HR 1.77), and high stride length variability (HR 1.58) were significantly associated with increased dementia risk after adjusting for covariates.
- These associations were consistent in both men and women.
Conclusions:
- Reduced gait function, characterized by slower speed, shorter stride length, and increased variability, is a significant predictor of incident dementia.
- The association between gait parameters and dementia risk is independent of sex.
- Quantitative gait analysis offers a valuable, multifaceted approach for assessing dementia risk in older adults.
More Related Videos
Related Concept Videos
01:30Dementia
562
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
562
02:12Relationship Formation
46.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
01:28Ending Relationships
181
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
181
01:26Variables Affecting Phosphorescence and Fluorescence
1.5K
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
1.5K
01:27Relationship Growth
209
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
209
01:11Variability: Analysis
500
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
The range is a simple measure of variability, indicating the difference between the highest and...
500