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Updated: Jan 28, 2026
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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
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Fast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complex
Zeynep Aytac1, Semran Ipek2, Ismail Erol3
1Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, 06800, Turkey.
Colloids and Surfaces. B, Biointerfaces
|March 11, 2019
Summary
Electrospun gelatin nanofibers successfully encapsulated a ciprofloxacin/hydroxypropyl-beta-cyclodextrin complex. This enhanced drug solubility and fast dissolution, offering a promising drug delivery system.
Area of Science:
- Biomaterials Science
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Ciprofloxacin (CIP) is a widely used antibiotic with limited solubility.
- Hydroxypropyl-beta-cyclodextrin (HPβCD) is a common host molecule used to improve drug solubility.
- Electrospun nanofibers offer a high surface area-to-volume ratio for drug encapsulation.
Purpose of the Study:
- To develop and characterize electrospun gelatin nanofibers encapsulating a ciprofloxacin/hydroxypropyl-beta-cyclodextrin inclusion complex (IC).
- To investigate the complexation efficiency and physical properties of the encapsulated drug.
- To evaluate the dissolution characteristics of the developed nanofibrous matrix.
Main Methods:
- Computational modeling (van der Waals forces) to predict complexation.
- Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) to confirm complex formation.
- Phase solubility studies to quantify solubility enhancement.
- Scanning electron microscopy (SEM) to analyze nanofiber morphology.
- Electrospinning technique to fabricate gelatin nanofibers.
Main Results:
- Computational modeling and spectroscopic studies confirmed the formation of a CIP/HPβCD host/guest inclusion complex.
- HPβCD significantly enhanced the aqueous solubility of CIP.
- Electrospun gelatin nanofibers encapsulating the CIP/HPβCD-IC exhibited a bead-free morphology with a diameter of approximately 90 nm.
- The nanofibrous mat loaded with CIP/HPβCD-IC showed significantly faster dissolution in water compared to CIP-loaded nanofibers without HPβCD.
Conclusions:
- Electrospun gelatin nanofibers effectively encapsulate CIP/HPβCD inclusion complexes.
- The developed system demonstrates improved drug solubility and enhanced dissolution rates.
- This approach holds potential for advanced drug delivery applications requiring rapid drug release.
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