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Advanced electrospun nanofibrous architectures for multidrug delivery systems
1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Sariyer, 34467, Istanbul, Turkey. topuzf@itu.edu.tr.
Chemical Communications (Cambridge, England)
|July 22, 2026
Summary
Advanced electrospun materials offer precise control for multi-drug combination therapy, enhancing treatment for complex diseases. Structural design significantly influences drug release, improving therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Complex diseases necessitate multi-drug therapies due to single-drug limitations.
- Electrospinning provides a versatile platform for creating advanced drug delivery systems.
Purpose of the Study:
- To review recent advancements in electrospun structures for multi-drug combination therapy.
- To analyze how structural design impacts drug release kinetics and therapeutic efficacy.
Main Methods:
- Coaxial and multiaxial electrospinning for core-shell architectures.
- Fabrication of bilayer, multilayer, Janus, and side-by-side fiber structures.
- Analysis of polymer choice, drug loading, and release profiles.
Main Results:
- Bilayer/multilayer structures facilitate programmed and sustained drug release.
- Core-shell designs ensure synchronized delivery and minimize burst release.
- Janus/side-by-side fibers enable spatially distinct co-delivery of incompatible agents.
Conclusions:
- Electrospun structures offer tunable drug release profiles for combination therapy.
- Structural engineering is key to optimizing multi-drug delivery systems.
- Addressing translational challenges is crucial for clinical application of electrospun therapies.
