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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Recent Advances in Cyclodextrin-Based Nanoscale Drug Delivery Systems.
1Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Turkey.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|October 31, 2024
Summary
Cyclodextrins (CDs) are versatile cyclic oligosaccharides used in drug delivery. Their unique structure enhances drug solubility, bioavailability, and stability in various nanoscale systems.
Area of Science:
- Biochemistry and Pharmaceutical Sciences
- Materials Science and Nanotechnology
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with a toroidal shape, featuring a hydrophobic interior and hydrophilic exterior.
- This structure enables CDs to act as solubilizers, stabilizers, and bioavailability enhancers in pharmaceutical formulations.
- CDs are increasingly integrated into nanoscale drug delivery systems due to their versatile properties.
Purpose of the Study:
- To review recent advancements in cyclodextrin-functionalized nanoscale drug delivery platforms.
- To analyze the physicochemical and toxicological aspects of CDs and their impact on drug bioavailability.
- To summarize the applications of CD-based nanomaterials in drug delivery.
Main Methods:
- Compilation and analysis of recent scientific literature on CD-functional nanoscale drug delivery systems.
- Review of studies focusing on physicochemical properties, toxicological profiles, and drug complexation of CDs.
- Categorization of applications based on nanomaterial type (polymeric, hybrid, lipid-based, nanofibers) and CD function.
Main Results:
- CDs effectively solubilize hydrophobic drugs, enabling high drug loading and enhancing bioavailability.
- Supramolecular complexation with CDs facilitates the engineering of advanced nanomaterials.
- CD-functionalized systems, including nanoparticles and nanofibers, demonstrate significant potential for drug delivery applications.
- CDs are primarily used for drug solubilization and loading, with some applications utilizing supramolecular complexation for system construction.
Conclusions:
- Cyclodextrin-based nanoscale drug delivery systems offer significant advantages in drug solubilization, loading, bioavailability enhancement, and stability.
- The versatility of CDs allows for their integration into diverse nanomaterial platforms for targeted therapeutic applications.
- Further research is needed to address current challenges and optimize the future development of CD-functionalized drug delivery systems.
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