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Related Concept Videos

Pericarditis I: Introduction01:22

Pericarditis I: Introduction

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

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The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
338
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

351
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
351
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

319
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
319
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Related Experiment Video

Updated: Jan 28, 2026

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Idiopathic Pericarditis-an Autoinflammatory Disease?

Norbert Blank1, Hanns-Martin Lorenz2

  • 1Department of Medicine V, Amyloidosis Center and Division of Haematology, Oncology and Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. norbert.blank@med.uni-heidelberg.de.

Current Rheumatology Reports
|March 11, 2019
PubMed
Summary

Idiopathic pericarditis, often of unknown cause, is increasingly viewed as an autoinflammatory disease. Treatments targeting the innate immune system, like colchicine, show effectiveness in managing acute and recurrent pericarditis.

Keywords:
Acute pericarditisAutoinflammationColchicineInflammasomeInterleukin-1βRecurrent pericarditis

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Area of Science:

  • Cardiology
  • Immunology
  • Rheumatology

Background:

  • Idiopathic acute and recurrent pericarditis are rare conditions with unclear origins.
  • Understanding their triggers, mechanisms, and treatments is crucial for patient management.

Purpose of the Study:

  • To review the known trigger factors for acute and recurrent pericarditis.
  • To explore the underlying pathomechanisms, focusing on the innate immune system.
  • To discuss current and emerging treatment options for these conditions.

Main Methods:

  • Review of existing literature on pericarditis.
  • Analysis of pathomechanistic concepts, including the role of the innate immune system.
  • Evaluation of clinical trial data for treatment efficacy.

Main Results:

  • Viral infections and cardiac procedures are potential triggers, but many cases remain idiopathic.
  • The innate immune system plays a significant role in the pathogenesis.
  • Colchicine and anti-IL1β therapies have demonstrated effectiveness in controlling pericarditis attacks.

Conclusions:

  • Acute and recurrent pericarditis should be considered autoinflammatory diseases.
  • Targeting innate immune system activation is a promising therapeutic strategy.
  • Further research into the autoinflammatory basis of idiopathic pericarditis is warranted.