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Updated: Jan 28, 2026
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High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
Published on: June 2, 2014
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Structure-function relationship between a natural cosmetic active ingredient and the olfactory receptor OR2AT4
L Verzeaux1, S Richer1, J Viguier1
1SILAB R&D Department, Brive, France.
International Journal of Cosmetic Science
|March 12, 2019
Summary
Researchers identified a natural molecule from coconut flour that stimulates skin cell migration by activating the olfactory receptor OR2AT4. This discovery offers a new avenue for cosmetic ingredients promoting skin repair and epithelialization.
Area of Science:
- Dermatology and Molecular Biology
- Cosmetic Science
- Olfactory Receptor Research
Background:
- The olfactory receptor OR2AT4 plays a role in epidermal renewal.
- No cosmetic active ingredients are known to activate OR2AT4.
- Stimulating keratinocyte migration is crucial for skin repair.
Purpose of the Study:
- To identify a natural molecule that binds to OR2AT4.
- To investigate the molecule's ability to stimulate keratinocyte migration.
- To explore potential cosmetic applications for skin regeneration.
Main Methods:
- Extraction of natural molecules from Cocos nucifera flour.
- In vitro evaluation of extract efficacy on keratinocyte migration.
- Identification of molecules using UPLC-MS/MS and molecular docking.
Main Results:
- Cocos nucifera flour extract significantly enhanced keratinocyte migration via OR2AT4.
- Butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside was identified as a key active molecule.
- Molecular docking confirmed butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside interaction with OR2AT4.
Conclusions:
- A natural molecule from Cocos nucifera flour interacts with OR2AT4.
- This interaction promotes keratinocyte migration and epithelialization.
- Highlights a novel natural ingredient for cosmetic applications in skin repair.
Keywords:
NMR/FTIR/MASS spectroscopyclaim substantiation in vivo/in vitromolecular modellingolfactory receptorskin physiology/structureMore Related Videos
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