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Focus on the Correlations between Alzheimer's Disease and Type 2 Diabetes
Vincenzo Fiore1,2, Antonia De Rosa3, Paolo Falasca4
1Unit of Internal Medicine and Geriatrics-Unit of Diabetology, "S. Giovanni Evangelista" Hospital, Via Parrozzani 3, 00019, Tivoli (RM), Italy.
Endocrine, Metabolic & Immune Disorders Drug Targets
|March 12, 2019
Summary
Diabetes and Alzheimer's disease are rising globally. Shared factors like inflammation and oxidative stress link these conditions, suggesting diabetes management may help prevent cognitive decline.
Area of Science:
- Neuroscience
- Endocrinology
- Pathology
Background:
- Increasing global prevalence of diabetes mellitus and Alzheimer's disease presents significant societal and healthcare challenges.
- Traditionally viewed as independent, growing evidence highlights intricate links between diabetes and Alzheimer's disease.
Purpose of the Study:
- To review and analyze shared features between Alzheimer's disease and diabetes mellitus.
- To elucidate the correlation between these two prevalent chronic conditions.
Main Methods:
- Literature review analyzing commonalities between Alzheimer's disease and diabetes mellitus.
- Examination of pathogenetic factors contributing to the coexistence of both diseases.
Main Results:
- Shared pathogenetic factors include chronic inflammation, oxidative stress, and mitochondrial dysfunction.
- Adiponectin deficiency, altered plasma cholinesterase activity, and vascular damage are implicated in the comorbidity of Type 2 Diabetes and Alzheimer's Disease.
Conclusions:
- Understanding the link between diabetes and Alzheimer's is crucial for effective management.
- Proper diabetes management, including diet, exercise, and glycemic control, may help prevent cognitive decline and Alzheimer's disease.