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Direct ink writing with high-strength and swelling-resistant biocompatible physically crosslinked hydrogels
Pan Jiang1, Changyou Yan, Yuxiong Guo
1State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. wangxl@licp.cas.cn.
Biomaterials Science
|March 12, 2019
Summary
This study developed strong, swelling-resistant hydrogels using 3D printing of polyvinyl alcohol (PVA) and κ-carrageenan. These biocompatible materials create excellent microenvironments for cell culture, advancing tissue engineering and regenerative medicine.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- Three-dimensional (3D) printing of hydrogels shows promise for biomedical applications.
- Limited availability of printable hydrogels with high strength and swelling resistance hinders progress.
Purpose of the Study:
- To fabricate robust and swelling-resistant hydrogel structures using direct ink writing (DIW).
- To investigate the potential of hybrid hydrogel inks for advanced biomedical applications.
Main Methods:
- Direct ink writing (DIW) of hybrid hydrogel inks composed of polyvinyl alcohol (PVA) and κ-carrageenan.
- Utilizing freezing and thawing cycles to induce physical crosslinking and enhance material properties.
Main Results:
- The DIW-printed hydrogels exhibited enhanced mechanical properties and swelling resistance due to physically crosslinked networks.
- Resultant hydrogels demonstrated excellent cytocompatibility, promoting cell attachment and proliferation within grid architectures.
- The materials provided suitable microenvironments for cell culture, supporting cell stretching and integration.
Conclusions:
- Physically crosslinked hybrid hydrogels offer high strength, swelling resistance, and biocompatibility.
- The DIW technique is compatible with these hydrogels for fabricating complex structures.
- These advanced hydrogels hold significant potential for tissue engineering, drug delivery, bone regeneration, and implant medicine.
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