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Published on: June 22, 2016
Effect of operation on B and T lymphocyte counts
Journal of Surgical Oncology
|January 1, 1978
Summary
Postoperative changes in B and T lymphocytes were studied in 21 patients. B-cell percentages increased, while total lymphocyte and T-cell counts temporarily decreased, especially after abdominal surgery, before returning to normal within a week.
Area of Science:
- Immunology
- Surgical Oncology
- Clinical Research
Background:
- Surgical procedures can impact immune cell populations.
- Understanding lymphocyte dynamics is crucial for patient recovery and immune response.
- Previous literature on postoperative lymphocyte changes requires further clinical investigation.
Purpose of the Study:
- To investigate the preoperative and postoperative changes in peripheral B and T lymphocyte counts.
- To analyze these changes in patients with breast carcinoma, sarcoma, and benign diseases.
- To correlate lymphocyte count variations with surgical site, particularly intraabdominal operations.
Main Methods:
- Peripheral blood samples were collected from 21 patients.
- B and T lymphocyte counts were measured preoperatively and on postoperative days one and two.
- Statistical analysis was performed to compare lymphocyte counts before and after surgery.
Main Results:
- A majority of patients showed an increased percentage of B-cells on postoperative days one and two.
- A decrease in total lymphocyte count and fast-reacting T lymphocyte numbers was observed on postoperative day one, particularly in patients undergoing intraabdominal surgery.
- Lymphocyte counts generally returned to preoperative levels within one week following surgery.
Conclusions:
- Surgical stress induces transient alterations in peripheral lymphocyte subsets.
- B-cell percentages increase, while T-cell numbers and total lymphocyte counts decrease postoperatively.
- These immune changes are temporary and typically resolve within a week.
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