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Related Experiment Video

Updated: Jan 28, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

High glucose levels affect retinal patterning during zebrafish embryogenesis.

Amitoj Singh¹, Hozana Andrade Castillo^2,3, Julie Brown¹

¹Deakin University, School of Medicine, Faculty of Health, 75 Pigdons Road, Waurn Ponds, Geelong, VIC, 3216, Australia.

Scientific Reports

|March 13, 2019

Summary

This summary is machine-generated.

Maternal hyperglycemia negatively impacts fetal eye development, causing retinal defects. Early and adult retinal assessments are recommended for infants born to diabetic mothers.

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A Novel Light Damage Paradigm for Use in Retinal Regeneration Studies in Adult Zebrafish

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Published on: October 24, 2013

Area of Science:

Developmental biology
Ophthalmology
Endocrinology

Background:

Maternal hyperglycemia, from pre-existing or gestational diabetes, poses risks to fetal development.
Known risks include post-natal obesity and impaired glucose tolerance.
The effect of maternal hyperglycemia on the developing fetal retina remains largely unknown.

Purpose of the Study:

To investigate the impact of maternal hyperglycemia on embryonic retinal development.
To establish a zebrafish model for studying gestational hyperglycemia's effects on the retina.

Main Methods:

Utilized zebrafish embryos (wild-type and transgenic) exposed to varying D-Glucose concentrations (0, 4, 5%).
Mimicked pulsatile glycemic fluctuations experienced by fetuses of diabetic mothers.
Analyzed ocular defects, retinal cell layer thickness, macrophage presence, and cell counts (Müeller glial, retinal ganglion cells).

Main Results:

High-glucose exposure induced significant ocular defects in zebrafish embryos.
Observed were altered retinal cell layer thickness and increased macrophage presence.
A decrease in Müeller glial and retinal ganglion cells was noted following high-glucose exposure.

Conclusions:

Gestational hyperglycemia, modeled in zebrafish, is detrimental to embryonic retinal development.
Glucose exposure can lead to lasting retinal abnormalities.
Retinal screening in infants of diabetic mothers is warranted for early and adult life surveillance.