Dynamic changes in purine catabolism in patients with acute coronary syndrome that underwent percutaneous coronary
Olga Visternichan1, Seyed Farzad Jalali2, Dana Taizhanova1
1Karaganda State Medical University, Karaganda, Kazakhstan.
Insights
Increased plasma purine catabolites, including guanine and uric acid, may indicate inflammation and instability in coronary artery plaques after percutaneous coronary intervention (PCI). These markers could signal restenosis risk in patients.
Area of Science:
- Biochemistry
- Cardiology
- Medical Diagnostics
Background:
- Cardiovascular diseases are a leading global cause of death, necessitating early diagnosis and treatment.
- Identifying novel biochemical markers is crucial for detecting complications post-coronary revascularization.
- Acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI) are key areas of cardiovascular research.
Purpose of the Study:
- To investigate changes in purine catabolites in ACS patients before and after PCI.
- To compare purine catabolite levels in ACS patients with a healthy control group.
- To evaluate the potential of purine catabolites as early diagnostic markers for post-PCI complications.
Main Methods:
- Thirty-five ACS patients (mean age 57±17 years) and 35 healthy controls were enrolled.
- Plasma levels of guanine, hypoxanthine, adenine, xanthine, and uric acid were measured before and 3 days after PCI.
- Purine catabolites were determined using the Oreshnikov E.V (2008) method.
Main Results:
- ACS patients showed elevated concentrations of guanine, hypoxanthine, adenine, xanthine, and uric acid compared to normal ranges prior to PCI.
- These purine catabolite levels remained significantly elevated 3 days after PCI.
- Statistical analysis indicated significant increases (P<0.001) in all measured purine catabolites.
Conclusions:
- Elevated plasma purine catabolites suggest inflammation and instability of coronary artery plaques.
- These markers may serve as indicators of restenosis in patients who have undergone PCI.
- Further research could validate purine catabolites as valuable biomarkers in cardiovascular disease management.
Background:
Cardiovascular diseases are global problems. They are causes of death in about 43% of people worldwide and may become the most widespread reason of death by 2020. The prognosis is directly dependent to immediate diagnosis and on time treatment. Introduction of new biochemical markers as the early diagnosis of complications after coronary revascularization is very important in this period. Herein, we assayed the changes of purine catabolites in patients with acute coronary syndrome (ACS) before and after percutaneous coronary intervention (PCI) in comparison with control group.
Methods:
Thirty five ACS patients (20 males and 15 females) were included (57±17 years old) in the study. The determination of intermediates of purine catabolism as guanine, hypoxanthine (GCS), adenine, xanthine (Kc) and uric acid (MK) were assayed before and 3 days after PCI. Conditionally, 35 healthy-matched persons were included in the control group. Purine catabolites were determined in plasma through the method of Oreshnikov E.V (2008).
Results:
In ACS patients, prior to PCI, there was a tendency to increase the concentration of guanine (P=0.001), hypoxanthine (P=0.002) adenine (P=0.0003), xanthine (P=0.000003) and uric acid (P=-0.000001) relative to the upper limits of normal ranges. And on the third day after PCI, there was the second tendency to increase the levels of guanine (P=0.000001), hypoxanthine (P=0.000001) adenine (P=0.0000001), xanthine (P=0.000001) and uric acid (P=0.0000001) relative to upper limits of normal ranges.
Conclusion:
Increment of plasma purine catabolites can be a marker of inflammation and instability of coronary artery plaques and may be used as a restenosis marker in patients with history of PCI.
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