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Updated: Jan 27, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein
Tingting Liu1, Gaopan Dong1, Feng Xu1
1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Abstract:
B-cell-lymphoma-2-gene (Bcl-2) family proteins play a central role in regulating programmed cell death. In cancer, antiapoptotic Bcl-2 proteins, such as Bcl-2 and Mcl-1, are overexpressed. However, there are few developed labeling techniques for tracing the dynamic processes of Bcl-2. To study the physiological process of Bcl-2 protein, a novel series of small-molecule fluorescent probes (1-3) were designed and evaluated for their labeling properties. Our probes can be applied to the identification of tumor-tissue slices and the differentiation of tumor and normal tissues effectively, a feature that renders these probes compatible with future cancer diagnosis in clinical practice.
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