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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.4K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

829
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
829
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

855
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
855
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

935
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
935
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

267
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
267
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

313
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
313

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Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
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Multimodality imaging in ischaemic heart failure.

Jeroen J Bax1, Marcelo Di Carli2, Jagat Narula3

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.

Lancet (London, England)
|March 13, 2019
PubMed
Summary
This summary is machine-generated.

Modern non-invasive imaging is crucial for assessing heart failure causes, guiding prognosis, and determining therapies like revascularization or valve repair. This evaluation aids in selecting optimal treatments beyond medication.

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Gene Transfer for Ischemic Heart Failure in a Preclinical Model
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Related Experiment Videos

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Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Heart failure necessitates comprehensive assessment of its causes, pathophysiology, and hemodynamics.
  • Modern non-invasive imaging modalities are essential for evaluating cardiac structure and function.

Purpose of the Study:

  • To outline a systematic approach for evaluating heart failure using non-invasive imaging.
  • To highlight how imaging guides therapeutic decisions beyond optimized medical therapy.

Main Methods:

  • Stepwise assessment of left ventricular size and function.
  • Evaluation of coronary artery disease, mitral regurgitation, pulmonary hypertension, and right ventricular function.
  • Assessment of tricuspid regurgitation.

Main Results:

  • Non-invasive imaging provides critical data for prognosis and therapeutic planning.
  • Imaging findings can guide decisions on revascularization, defibrillator implantation, and valve repair/replacement.
  • Evidence from randomized controlled trials guiding therapy with non-invasive imaging is limited.

Conclusions:

  • A comprehensive non-invasive imaging strategy is vital for managing heart failure patients.
  • Imaging plays a key role in personalizing treatment strategies for heart failure.
  • Further research is needed to strengthen the evidence base for imaging-guided therapies in heart failure.