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Amphiregulin and ocular axial length
Li Dong1, Xu Han Shi1, Yi Kun Kang2
1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Acta Ophthalmologica
|March 13, 2019
Summary
Amphiregulin may play a role in eye growth. Blocking amphiregulin reduced ocular axial elongation in guinea pigs, while administering it increased eye growth, suggesting its involvement in myopia development.
Area of Science:
- Ophthalmology
- Developmental Biology
- Molecular Biology
Background:
- Ocular axial elongation is a key factor in myopia development.
- The role of specific signaling molecules, like amphiregulin, in this process requires further investigation.
Purpose of the Study:
- To investigate the potential role of amphiregulin as a messenger molecule in ocular axial elongation.
- To determine if modulating amphiregulin levels affects eye growth in a guinea pig model.
Main Methods:
- Lens-induced myopia was created in guinea pigs.
- Intraocular injections of amphiregulin antibody or amphiregulin were administered.
- Ocular biometry, histology, and immunohistochemistry were performed post-mortem.
Main Results:
- Amphiregulin antibody administration dose-dependently reduced axial elongation and thickened the sclera in myopic eyes.
- Amphiregulin injections increased axial elongation in non-myopic eyes.
- Increased amphiregulin visualization and mRNA expression were observed in myopic eyes.
Conclusions:
- Amphiregulin is associated with ocular axial elongation in young guinea pigs.
- Modulating amphiregulin levels can influence eye growth, suggesting a potential therapeutic target for myopia.
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