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Purification of a High Molecular Mass Protein in Streptococcus mutans
Published on: September 14, 2019
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DMBT1 involvement in the human aortic endothelial cell response to Streptococcus mutans
1Department of Preventive Dentistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Molecular Oral Microbiology
|March 13, 2019
Summary
Deleted in malignant brain tumors 1 (DMBT1) protects against Streptococcus mutans-induced cardiovascular disease (CVD) in human aortic endothelial cells. DMBT1 reduces bacterial adhesion and invasion, mitigating CVD-related cytokine production.
Area of Science:
- Microbiology
- Cardiovascular Biology
- Immunology
Background:
- Streptococcus mutans is linked to dental caries and cardiovascular disease (CVD).
- S. mutans invades human aortic endothelial cells (HAECs), increasing CVD-related cytokine production.
- Deleted in malignant brain tumors 1 (DMBT1) is involved in S. mutans cariogenesis but its role in CVD is unknown.
Purpose of the Study:
- Investigate DMBT1 expression in HAECs stimulated by S. mutans.
- Examine DMBT1's role in the interaction between S. mutans and HAECs.
Main Methods:
- Stimulated HAECs with S. mutans strains.
- Assessed DMBT1 expression levels.
- Evaluated S. mutans adherence and invasion in DMBT1-knockdown and DMBT1-producing HAECs.
- Measured cytokine production in response to S. mutans.
Main Results:
- S. mutans increased DMBT1 production in HAECs.
- DMBT1 knockdown enhanced S. mutans adherence and invasion.
- DMBT1 reduced bacterial invasion and cytokine production.
- Externally added DMBT1 inhibited bacterial adherence.
Conclusions:
- DMBT1 expression is upregulated by S. mutans in HAECs.
- DMBT1 plays a protective role against S. mutans-induced CVD processes.
- DMBT1 inhibits S. mutans adherence and invasion, reducing inflammation.
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