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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Association between periodontal disease and malignant soft tissue sarcomas
Takatoshi Hiroshimaya1, Yusuke Fujimoto2, Hiromi Sasaki2
1Department of Preventive Dentistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Oral Diseases
|January 9, 2024
Summary
Severe periodontitis, a form of periodontal disease, is significantly linked to malignant soft tissue sarcoma (MSTS) in orthopedic surgery patients. This finding highlights a potential connection between oral health and this rare cancer.
Area of Science:
- Orthopedic Surgery
- Periodontology
- Oncology
Background:
- Malignant soft tissue sarcoma (MSTS) is rare but observed in orthopedic surgery patients.
- The link between periodontal disease and MSTS is not well-established, unlike its association with other cancers.
- This study explores the relationship between periodontal disease and MSTS in individuals undergoing orthopedic procedures.
Purpose of the Study:
- To investigate the association between periodontal disease and MSTS in patients undergoing orthopedic surgery.
- To determine if periodontal inflammation is a risk factor for MSTS development in this population.
Main Methods:
- Retrospective analysis of 115 orthopedic surgery patients (2017-2021).
- Propensity score (PS) matching and inverse probability of treatment weighting (IPTW) to adjust for patient background.
- Periodontal status assessed via periodontal inflamed surface area, probing depth, and bleeding on probing.
Main Results:
- Severe periodontitis showed a significant association with MSTS after PS adjustment (OR 2.81, p=0.04).
- IPTW analysis also confirmed a significant association between severe periodontitis and MSTS (OR 3.21, p=0.01).
Conclusions:
- The study indicates a significant association between periodontal inflammation and MSTS.
- Findings suggest that severe periodontitis may be a risk factor for MSTS in patients undergoing orthopedic surgery.
