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Indicators02:39

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Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
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Updated: Jan 27, 2026

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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[Free light chains assay: Indications and methods].

J-P Martellosio1, X Leleu2, P Roblot1

  • 1Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France.

La Revue De Medecine Interne
|March 14, 2019
PubMed
Summary
This summary is machine-generated.

The serum free light chains (sFLC) assay, particularly the Freelite® assay, is crucial for diagnosing and monitoring plasma cell dyscrasias like myeloma and amyloidosis. It offers higher sensitivity than traditional tests and aids in risk stratification and treatment response assessment.

Keywords:
Chaines légères libres sériquesFree light chainsFreelite(®)Gammapathie monoclonaleIndicationsMonoclonal gammopathyPathophysiologyPhysiopathologie

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Area of Science:

  • Clinical Chemistry
  • Hematology
  • Oncology

Background:

  • Serum free light chains (sFLC) are key markers in plasma cell dyscrasias.
  • sFLC assays are recommended for diagnosing monoclonal gammopathy alongside other methods.
  • These assays hold prognostic value and assess treatment response and relapse.

Purpose of the Study:

  • To highlight the importance of sFLC assays, especially the Freelite® assay, in managing plasma cell dyscrasias.
  • To compare the Freelite® assay with other available methods.
  • To discuss the expanding role of sFLC assays in clinical practice.

Main Methods:

  • Review of current sFLC assay availability and validation in France.
  • Comparison of Freelite® assay sensitivity against Bence Jones protein test.
  • Analysis of Freelite® assay's integration into diagnostic criteria and clinical applications.

Main Results:

  • The Freelite® assay is the gold standard, with other assays needing validation and not being interchangeable.
  • Freelite® assay demonstrates higher sensitivity than Bence Jones protein testing for light chain myeloma.
  • It is essential for monitoring light chain amyloidosis and risk stratification in monoclonal gammopathy of undetermined significance.

Conclusions:

  • The Freelite® assay is indispensable for managing myeloma and amyloidosis.
  • Its utility is recognized in diagnosing multiple sclerosis and screening for monoclonal gammopathy in renal failure.
  • The application of sFLC assays is expected to broaden, potentially including autoimmune diseases.