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Updated: Jan 27, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Photodynamic activity and DNA binding studies of Pd@SiO2 core-shell nanoparticles in vitro
K I Dhanalekshmi1, K Sangeetha2, K S Meena2
1Dept. of Chemistry, Bharath Institute of Higher Education & Research, Bharath University, Chennai 600 073, Tamil Nadu, India.
Abstract:
Metal-semiconductor core-shell type Pd@SiO2 nanoparticles (NPs) were successfully synthesized by Stober's method and the product was characterized by UV-vis, XRD, FT-IR, SEM, HR-TEM and EDX techniques. In vitro Photodynamic activity and DNA binding studies of Pd@SiO2 core shell nanoparticles were studied. Cell viability of the core-shell nanoparticles against HeLa cell line was screened by MTT assay after exposing at different light doses. The outcome of the present study indicates that the core-shell Pd@SiO2 NPs are highly stable and exhibited strong photodynamic efficiency under LED light illumination in HeLa cells. The results indicated that SiO2 supported on the surface of Pd NPs not only prevented the aggregation in addition exhibited remarkable photodynamic activity.
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