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05:17
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
379
Biomarkers in Non-Small Cell Lung Cancers: Indian Consensus Guidelines for Molecular Testing.
Kumar Prabhash1, Suresh H Advani2, Ullas Batra3
1Department of Medical Oncology, Tata Memorial Hospital, Tata Memorial Center, Mumbai, Maharashtra, India. kprabhash1@gmail.com.
Advances in Therapy
|March 14, 2019
Summary
This guideline offers Indian oncologists a practical reference for molecular biomarker testing in non-small cell lung cancer (NSCLC). It addresses challenges and provides recommendations for accurate biomarker identification to improve patient care.
Area of Science:
- Oncology
- Molecular Pathology
- Genomics
Background:
- Advanced non-small cell lung cancer (NSCLC) diagnosis has been transformed by molecular targets and targeted therapies.
- Implementing molecular screening for predictive biomarkers in India faces operational and logistical hurdles.
- A consensus guideline is needed to facilitate biomarker testing in Indian clinical settings.
Purpose of the Study:
- To establish a consensus guideline for biomarker testing in NSCLC for Indian medical oncologists, molecular pathologists, and pathologists.
- To provide a competent reference addressing the challenges of molecular screening in India.
- To support informed decision-making for improved NSCLC patient care.
Main Methods:
- Consensus development involving Indian medical oncologists, molecular pathologists, and pathologists.
- Summarization of key targetable mutations (e.g., EGFR, ALK, ROS1) and biomarkers (e.g., PD-L1) in NSCLC.
- Review of diagnostic tests including immunohistochemistry, FISH, PCR, and NGS, with pros and cons.
- Inclusion of pre-analytical procedure considerations and quality assessment checklists.
Main Results:
- The guideline details important targetable mutations and biomarkers for NSCLC.
- It critically evaluates various diagnostic testing modalities.
- An algorithm for diagnostic decision-making and a laboratory quality checklist are provided.
Conclusions:
- This guideline serves as a crucial reference for biomarker testing in NSCLC in India.
- It aims to overcome implementation challenges and standardize molecular strategies.
- The recommendations will aid healthcare professionals in making informed choices for better NSCLC management.
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