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Updated: Jan 27, 2026
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Chronic kidney disease and the gut microbiome
Gerren P Hobby1, Oleg Karaduta2, Giuseppina F Dusio1
1Division of Nephrology, University of Arkansas for Medical Sciences , Little Rock, Arkansas.
American Journal of Physiology. Renal Physiology
|March 14, 2019
Summary
The gut microbiome impacts chronic kidney disease (CKD) by altering gut bacteria, increasing toxins, and damaging the intestinal barrier, accelerating kidney injury. Therapeutic strategies aim to modify this pathway.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- The gut microbiome, a complex bacterial community, influences human health and disease.
- Chronic kidney disease (CKD) is associated with significant alterations in gut microbial composition.
- Elevated urea levels in CKD promote gut-derived toxins and compromise intestinal barrier integrity, exacerbating kidney damage.
Purpose of the Study:
- To review the gut microbiome's role in the pathogenesis of CKD.
- To discuss methodologies for studying the gut microbiome in CKD.
- To explore therapeutic interventions targeting the gut microbiome in CKD.
Main Methods:
- Literature review of studies on gut microbiome and CKD.
- Analysis of research on gut-derived toxins and intestinal barrier function in CKD.
- Examination of current and proposed therapeutic strategies.
Main Results:
- CKD-induced changes in the gut microbiome contribute to disease progression.
- Gut-derived toxins and barrier dysfunction are key mechanisms linking microbiome alterations to kidney injury.
- Various interventions are being investigated to modulate the gut microbiome for CKD treatment.
Conclusions:
- The gut microbiome is a critical factor in CKD progression.
- Understanding the gut microbiome offers novel therapeutic targets for CKD.
- Further research is needed to develop effective microbiome-based therapies for CKD.
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