Related Experiment Video
Updated: Jan 27, 2026

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
Published on: September 1, 2023
Daily and Weekly Rehabilitation Delivery for Young Children With Gross Motor Delay: A Randomized Clinical Trial
Rachel Ferrante1, Sarah Hendershot, Kathy Baranet
1Nationwide Children's Hospital (Drs Ferrante, Hendershot, Baranet, Maitre, and Lo), Columbus, Ohio; The Ohio State University (Drs Barbosa, Pan, and Heathcock), Columbus, Ohio; Kettering College (Dr Carey), Kettering, Ohio.
Insights
This study investigates how often infants with cerebral palsy receive rehabilitation, aiming to find the best frequency for therapy to improve motor skills. Results will guide optimal rehabilitation dosing for young children.
Area of Science:
- Pediatric rehabilitation
- Neurology
- Developmental pediatrics
Background:
- Cerebral palsy (CP) is a common childhood motor disorder.
- Optimizing rehabilitation frequency is crucial for therapeutic response in infants with CP.
- Evidence-based recommendations for rehabilitation dosing in early childhood CP are lacking.
Purpose of the Study:
- To test the principle that rehabilitation frequency regulates therapeutic response in infants.
- To determine the short-term and long-term effects of different rehabilitation dosing protocols.
- To provide data informing optimal frequency of therapy for young children with CP.
Main Methods:
- Randomized controlled trial involving 75 infants (6-24 months) with cerebral palsy.
- Participants classified by Gross Motor Function Classification System (GMFCS) levels III-V (higher severity).
- Comparison of 3 dosing protocols with identical therapy hours but varying total duration.
Main Results:
- The study aims to identify significant differences in motor function and developmental outcomes based on rehabilitation frequency.
- Analysis will focus on both immediate and sustained effects of the different dosing strategies.
- Expected outcomes will highlight the impact of therapy frequency on therapeutic gains.
Conclusions:
- Findings will inform clinicians, families, and researchers on optimal rehabilitation frequency for infants with cerebral palsy.
- Recommendations will be provided to enhance motor function and development in young children with CP.
- This research addresses a critical gap in understanding rehabilitation dosing for early-onset pediatric neurological conditions.
Purpose:
The proposed project tests the principle that frequency of rehabilitation is an important regulator of therapeutic response in infants.
Methods:
We will randomize 75 infants with cerebral palsy, 6 to 24 months of age and/or Gross Motor Function Classification System levels III to V (higher severity), to determine the short-term and long-term effects of 3 dosing protocols consisting of an identical number of 2-hour sessions of the same motor learning-based therapy applied over a different total number of calendar weeks.
Results And Conclusions:
The results will inform clinicians, families, and scientists about dosing and will provide needed recommendations for frequency of rehabilitation to optimize motor function and development of young children with cerebral palsy.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Statistical Software for Data Analysis and Clinical Trials
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
Gross Anatomy of the Lungs
Gross Anatomy of the Stomach

