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Assisted Reproductive Technology and Epigenetics.

Anthony M DeAngelis1, Anne E Martini1, Carter M Owen2

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Summary
This summary is machine-generated.

Assisted reproductive technology (ART) may affect genomic imprinting, but current evidence suggests the risk of imprinting disorders in ART-conceived children is low. Further research is needed, but routine screening is not currently recommended.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Developmental Biology

Background:

  • Assisted reproductive technology (ART) accounts for 1.7% of US births annually.
  • Concerns exist regarding imprinting disorders in ART-conceived children, potentially linked to ART procedures affecting embryonic development.
  • Animal studies suggest ART may interfere with genomic imprinting, a process crucial for gene regulation.

Purpose of the Study:

  • To evaluate the association between assisted reproductive technology (ART) and imprinting disorders.
  • To review the evidence regarding ART's potential impact on genomic imprinting mechanisms.
  • To determine the necessity of screening ART-conceived children for imprinting disorders.

Main Methods:

  • Review of existing literature and studies on ART and imprinting disorders.
  • Analysis of reported DNA methylation alterations in ART-conceived children.
  • Assessment of limitations in current research, including study design and cohort sizes.

Main Results:

  • Some studies report altered DNA methylation patterns in ART-conceived children with imprinting disorders, but findings are inconsistent.
  • Rarity of imprinting disorders, varied ART protocols, and lack of robust control groups hinder definitive conclusions.
  • Current evidence indicates a low absolute risk of imprinting disorders following ART.

Conclusions:

  • The association between ART and imprinting disorders remains controversial and not definitively established.
  • Large, prospective studies focusing on molecular causes are required to clarify any potential link.
  • Routine screening for imprinting disorders in ART-conceived children is not warranted based on current evidence.