Related Experiment Video

Updated: Jan 27, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care-Part 1: The Non-Androgen-Targetable

Bryden Considine, Daniel P Petrylak

    Oncology (Williston Park, N.Y.)
    |March 14, 2019
    PubMed

    Insights

    New treatments are needed for advanced prostate cancer. Biomarker-driven therapies like targeted treatments and immuno-oncology offer potential for better outcomes and reduced toxicity in metastatic prostate cancer patients.

    Area of Science:

    • Oncology
    • Urology
    • Medical Research

    Background:

    • Prostate cancer is a leading cause of cancer death in men.
    • While survival has improved with hormone therapy for metastatic prostate cancer, disease progression remains a challenge.
    • There is a critical need for novel therapeutic strategies to improve outcomes.

    Purpose of the Study:

    • To review current and future directions for novel therapeutic targets in metastatic prostate cancer.
    • To explore the potential of biomarker-driven treatments.

    Main Methods:

    • Literature review of current research and clinical investigations.
    • Analysis of emerging therapeutic mechanisms in prostate cancer treatment.

    Main Results:

    • Second-generation hormone therapy has improved survival but not prevented progression for most metastatic prostate cancer patients.
    • Biomarker-driven treatments, including targeted therapies and immuno-oncology, are under investigation.
    • These novel approaches may offer reduced toxicity and improved efficacy.

    Conclusions:

    • Novel therapeutic mechanisms are essential for improving treatment and outcomes in metastatic prostate cancer.
    • Biomarker-driven therapies represent a promising future direction for managing advanced prostate cancer.
    • Further research into targeted therapies and immuno-oncology is warranted.

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