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Updated: Jan 27, 2026

Concentration of Virus Particles from Environmental Water and Wastewater Samples Using Skimmed Milk Flocculation and Ultrafiltration
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Variability in Cholesterolemic Response of Rats Consuming Skim Milk.

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Skim milk powder (SMP) does not consistently lower cholesterol in rats. Its hypocholesterolemic effect is transient and depends on diet composition and feeding timing shortly after weaning.

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Area of Science:

  • Nutrition Science
  • Biochemistry
  • Animal Nutrition

Background:

  • Dietary components significantly influence plasma cholesterol levels.
  • Understanding the impact of dairy products like skim milk powder (SMP) on lipid metabolism is crucial for nutritional science.

Purpose of the Study:

  • To investigate the hypocholesterolemic (cholesterol-lowering) properties of skim milk powder (SMP) in rats.
  • To determine the conditions under which SMP may affect plasma cholesterol (CH) levels.

Main Methods:

  • Rats were fed diets containing 25% SMP, with varying protein sources (casein, soy) and diet types (stock, semipurified).
  • Feeding trials were conducted over 5 to 16 weeks, with interventions initiated at different time points relative to weaning.
  • Plasma cholesterol levels were monitored to assess the effect of SMP consumption.

Main Results:

  • SMP did not consistently lower plasma cholesterol in rats across all experimental conditions.
  • A transient hypocholesterolemia was observed only when SMP was included in casein-based semipurified diets fed within one week of weaning.
  • The hypocholesterolemic effect was not observed with soy-based diets or stock diets, and appeared transient, facilitating normal post-weaning cholesterol decline.

Conclusions:

  • Consumption of skim milk powder (SMP) does not reliably induce hypocholesterolemia in rats.
  • The hypocholesterolemic effect of SMP is highly dependent on the timing of diet introduction post-weaning and the absence of other cholesterol-lowering dietary factors.
  • Observed transient effects suggest SMP may modulate the natural decline of plasma cholesterol during the post-weaning period.