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Published on: March 13, 2014
Effects in Rats of Cyclopropenoid Fatty Acids from Cottonseed Oil
Lucy L Fan1, Barney W Hilton1, Alan Wohlman1
1Research Department, Frito-Lay, Inc., 900 N. Loop 12, Irving, Texas 75061.
Abstract:
The effects of cyclopropenoid fatty acids naturally present in cottonseed oil have been investigated in rats by feeding diets containing 0, 60, 300, 600 and 3,000 μg of cyclopropenoid fatty acids/g for 3 and 6 months. At the end of 3 and 6 months of feeding, rats were sacrificed for histopathological and biochemical evaluations. Body weight, food consumption, physical appearance, organ weight, hematological profiles, histopathological indicators, liver microsomal protein, activity of NADPH-cytochrome c (P-450) reductase, and the hepatic contents of cytochromes P-450 and b5 were not distinctly different among the five groups of rats. However, there was a positive correlation between the amount of cyclopropenoid fatty acids deposited in the body fat and content of these fatty acids in the diets. The significance of these results is discussed.
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