Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

11.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

29.7K

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

1.4K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.4K
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

524
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
524
Photoluminescence: Applications01:14

Photoluminescence: Applications

1.1K
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controllable Protein Design by Prefix-Tuning Protein Language Models.

Journal of chemical information and modeling·2026
Same author

Single-round evolution of RNA aptamers with GRAPE-LM.

Nature biotechnology·2026
Same author

AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging.

Nature methods·2025
Same author

Biomolecular Interaction Prediction: The Era of AI.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

iMFP-LG: Identify Novel Multi-functional Peptides Using Protein Language Models and Graph-based Deep Learning.

Genomics, proteomics & bioinformatics·2024
Same author

Clinical Translation of Aptamers for COVID-19.

Journal of medicinal chemistry·2023

Related Experiment Video

Updated: Jan 27, 2026

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
08:23

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications

Published on: June 23, 2016

12.7K

Recent Advances in Aptamer Discovery and Applications.

Yang Zhang1, Bo Shiun Lai2, Mario Juhas3

  • 1College of Science, Harbin Institute of Technology, Shenzhen 518055, China. zhangyang07@hit.edu.cn.

Molecules (Basel, Switzerland)
|March 15, 2019
PubMed
Summary

Aptamers, which are DNA or RNA molecules, offer high specificity for various targets. This review highlights their advances in biosensing, biotechnology, and medicine, including diagnostics and therapeutics.

Keywords:
aptamerbiosensordiagnosticsnanorocketsystematic evolution of ligands by exponential enrichment (SELEX)therapeutics

More Related Videos

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

10.3K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.8K

Related Experiment Videos

Last Updated: Jan 27, 2026

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
08:23

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications

Published on: June 23, 2016

12.7K
Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

10.3K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.8K

Area of Science:

  • Biochemistry and Molecular Biology
  • Biotechnology
  • Medical Diagnostics and Therapeutics

Background:

  • Aptamers are single-stranded nucleic acid or synthetic XNA molecules with high affinity and specificity for diverse targets.
  • They are increasingly utilized in basic research, food safety, environmental monitoring, and clinical applications.
  • The field of aptamer research is rapidly advancing, necessitating updated reviews.

Purpose of the Study:

  • To provide an updated overview of recent advances in aptamer technology.
  • To emphasize the generation of aptamers and their diverse applications.
  • To discuss current limitations and future directions for aptamers.

Main Methods:

  • Literature review of recent scientific publications on aptamer generation and applications.
  • Focus on advancements in biosensing, biotechnology, and medicine.
  • Analysis of aptamer roles in diagnostics, therapeutics, target-specific delivery, and real-time detection.

Main Results:

  • Aptamers demonstrate significant potential in basic research, food safety, and environmental monitoring.
  • They are emerging as valuable tools for clinical diagnostics and therapeutic agents.
  • Recent progress shows promise in aptamer-based target-specific delivery and real-time detection.

Conclusions:

  • Aptamers are versatile molecules with broad applications across scientific and medical fields.
  • Continued research is crucial for overcoming limitations and realizing the full potential of aptamers.
  • Future directions include enhancing target-specific delivery and real-time detection capabilities.