Metabolic Alterations, Aggressive Hormone-Naïve Prostate Cancer and Cardiovascular Disease: A Complex Relationship
Simona Di Francesco1,2, Iole Robuffo3, Marika Caruso4,5
1Department of Medical and Oral Sciences and Biotechnologies, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy. docveronica@gmail.com.
Medicina (Kaunas, Lithuania)
|March 15, 2019
Summary
Metabolic disorders and cardiovascular disease are linked to aggressive prostate cancer. Early evaluation of these conditions alongside prostate cancer diagnosis is crucial for better patient outcomes.
Area of Science:
- Oncology
- Metabolic Medicine
- Cardiovascular Science
Background:
- Epidemiological studies suggest a link between metabolic alterations, cardiovascular disease, and aggressive prostate cancer, but consensus is lacking.
- Existing research presents conflicting results, potentially due to inconsistent risk factor identification.
Purpose of the Study:
- To review current literature on the association between metabolic disorders, aggressive hormone-naïve prostate cancer, and cardiovascular disease.
- To present clinical experience regarding the interplay between metabolic alterations, prostate cancer aggressiveness, and vascular conditions.
Main Methods:
- Literature search conducted in Scopus, Life Science Journals, and Index Medicus/Medline.
- Analysis of the relationship between metabolic alterations and aggressive prostate cancer, independent of hormone therapy.
- Evaluation of the role of coronary and carotid vasculopathy in advanced prostate cancer.
Main Results:
- Prostate cancer cells exhibit altered metabolic control, correlating with increased aggressiveness and mortality.
- Metabolic risk factors (obesity, hypertension, diabetes, dyslipidemia) and vascular diseases (coronary, carotid) are implicated in prostate cancer progression.
- Systemic inflammation and oxidative stress, associated with metabolic and cardiovascular issues, exacerbate prostate cancer aggressiveness.
Conclusions:
- Metabolic alterations and cardiovascular disease significantly impact aggressive and metastatic prostate cancer.
- Comprehensive assessment of metabolic health (obesity, diabetes, dyslipidemia, hypertension) and cardiovascular status (coronary, carotid disease) is recommended post-prostate cancer diagnosis.
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