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Updated: Jan 27, 2026
14:39
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
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[Consumption of phenolic compounds in the elderly population]
Andrea Cereceres Aragón1, Joaquín Rodrigo García1, Emilio Álvarez Parrilla1
1Universidad Autónoma de Ciudad Juárez.
Nutricion Hospitalaria
|March 15, 2019
Summary
Elderly individuals may not consume enough phenolic compounds for disease prevention. Increasing intake is recommended, as aging affects absorption and bioavailability of these antioxidants.
Area of Science:
- Gerontology
- Nutritional Science
- Biochemistry
Background:
- The aging population is growing, leading to an increased prevalence of age-related diseases.
- Phenolic compounds possess antioxidant properties crucial for preventing oxidative damage linked to disease onset.
- Aging alters factors influencing phenolic compound absorption, impacting their bioavailability.
Purpose of the Study:
- To review recent literature on phenolic compound consumption and its health implications in the elderly.
- To analyze the relationship between phenolic intake and chronic disease prevention in older adults.
Main Methods:
- A systematic literature search was conducted across academic databases (EBSCOHOST, PubMed, Science Direct).
- The search focused on total phenol consumption in older adults, with data analyzed and subclassified by chronic disease relevance.
Main Results:
- Phenolic compound intake in older adults varies widely, from 280 ± 130 to 2,771 ± 1,552 mg/day.
- Beneficial intake levels for cardiovascular diseases, metabolic syndrome, and diabetes range from 322 ± 153 to 2,861 mg/day.
Conclusions:
- Current phenolic compound consumption is insufficient for disease prevention in some elderly individuals; increased intake is advised.
- Factors like polyphenol transporter deficiencies modify required intake levels due to altered bioavailability.
- Further research on phenolic compounds in the elderly population is recommended due to limited existing studies.
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