Mutations in gliclazide-associated genes may predict poor bladder cancer prognosis

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Updated: Jan 27, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

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Weiheng Wen1, Jinru Gong2, Peili Wu1

  • 1Department of Endocrinology Zhujiang Hospital Southern Medical University Guangzhou China.

FEBS Open Bio
|March 15, 2019
PubMed

Insights

Gliclazide, a diabetes drug, may increase bladder cancer risk. Genomic analysis of associated genes suggests caution for diabetic cancer patients, particularly those with bladder cancer.

Area of Science:

  • Oncology
  • Pharmacology
  • Bioinformatics

Background:

  • Co-occurrence of diabetes and cancer presents treatment challenges.
  • The oncogenic potential of gliclazide, a common sulfonylurea, requires clarification.

Purpose of the Study:

  • To investigate the cancer-associated biological network of gliclazide.
  • To assess the risk of gliclazide in cancer patients, particularly bladder cancer.

Main Methods:

  • Utilized DrugBank and STRING to identify gliclazide targets and associated genes.
  • Performed Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
  • Conducted genomic analysis using cBioPortal.

Main Results:

  • Identified two primary gliclazide targets and 50 associated genes.
  • KEGG analysis revealed links to bladder cancer and the PI3K-AKT pathway, identifying four overlapping genes.
  • Genomic alterations in these four genes correlate with poor prognosis in bladder cancer patients.

Conclusions:

  • Gliclazide use warrants caution in diabetic cancer patients, especially those with bladder cancer.
  • The study demonstrates a network analysis approach for evaluating drug safety and interactions.
Keywords:
bioinformaticsbladder cancerdiabetesgliclazide

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