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Updated: Jan 27, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Most Promising Therapies in Interventional Cardiology
Mathieu Kerneis1,2, Tarek Nafee1, Megan K Yee1
1PERFUSE Study Group, Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 930 Commonwealth Ave, Boston, MA, 02215, USA.
Interventional cardiology has seen major advances, but 15% of acute coronary syndrome patients still face recurrent events. New therapies targeting inflammation and cholesterol, alongside AI-driven tools, promise improved outcomes for coronary artery disease.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Technology
Background:
- Interventional cardiology has undergone significant innovation over the past 40 years.
- Percutaneous interventions, including stenting, transcatheter aortic valve implantation (TAVI), and left atrial appendage closure, have revolutionized patient care.
- Despite advances, 15% of acute coronary syndrome (ACS) patients experience recurrent ischemic events within a year.
Purpose of the Study:
- To review promising emerging interventional cardiovascular therapies.
- Focus on novel treatments for coronary artery disease (CAD).
- Highlight advancements in diagnostics and AI for cardiovascular care.
Main Methods:
- Review of recent clinical research and emerging technologies in interventional cardiology.
- Analysis of data supporting inflammation and cholesterol efflux as therapeutic targets.
- Exploration of novel medical devices and artificial intelligence applications.
Main Results:
- Novel therapeutic targets, including inflammation and cholesterol efflux, show promise for improving CAD patient prognosis.
- New medical devices are being developed for early detection of cardiac events and support of high-risk interventions.
- Artificial intelligence (AI) is poised to enhance clinical decision-making and patient management through data analysis and procedural guidance.
Conclusions:
- Emerging therapies and technologies offer significant potential to improve outcomes for patients with coronary artery disease.
- Continued research into inflammation, cholesterol metabolism, and device innovation is crucial.
- AI integration in cardiology promises to augment clinical practice and patient prognostication.
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