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A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood
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Equine platelet concentrate preparation and validation.

Rana Bozorgmanesh1, K Gary Magdesian2, Julie W Sutton-Burges3

  • 1McGee Medicine Center, Hagyard Equine Medical Institute, Lexington, Kentucky.

Journal of Veterinary Internal Medicine
|March 15, 2019
PubMed
Summary
This summary is machine-generated.

This study developed a method for equine platelet concentrate (PC) production, achieving high platelet counts. The resulting PC met human transfusion standards, offering a potential new therapy for horses.

Keywords:
horsethrombocytethrombocytopeniatransfusion

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Area of Science:

  • Veterinary Medicine
  • Hematology
  • Transfusion Medicine

Background:

  • Platelet transfusions are crucial for managing bleeding disorders in horses.
  • Current options like whole blood or platelet-rich plasma may have limitations.
  • A standardized equine platelet concentrate (PC) is needed.

Purpose of the Study:

  • To develop and validate a method for producing equine platelet concentrate (PC).
  • To assess the quality and stability of the produced PC.
  • To determine if the equine PC meets established transfusion standards.

Main Methods:

  • Whole blood from six healthy horses was processed using centrifugation.
  • The resulting PC was stored at 22°C with continuous agitation.
  • Platelet count, pH, biochemical markers, and aggregometry were measured over seven days.

Main Results:

  • Equine PC consistently maintained a platelet count ≥550 × 10^3 cells/μL.
  • Platelet function (aggregometry) decreased significantly over time.
  • Biochemical parameters like pH, glucose, and lactate changed, but key indicators like LDH and AST remained stable, with no bacterial growth.

Conclusions:

  • The developed technique successfully produced equine platelet concentrate (PC).
  • The equine PC met the quality standards set by the American Association of Blood Banks for human PC.
  • This method offers a promising avenue for equine transfusion therapy.