Causes Of Primary Amenorrhea At Tertiary Level Hospital

Area of Science:

• Reproductive Endocrinology
• Gynecology
• Pediatric Endocrinology

Background:

• Primary amenorrhea affects numerous adolescent females, presenting significant emotional distress.
• Understanding the diverse etiologies is critical for effective patient management.

Purpose of the Study:

• To investigate the etiological spectrum of primary amenorrhea.
• To analyze the demographic and clinical characteristics of affected patients.
• To inform multidisciplinary management strategies.

Main Methods:

• A descriptive case series was conducted from December 2012 to September 2016.
• Data from 82 patients with primary amenorrhea were collected.
• Investigations followed a standardized unit protocol.

Main Results:

• Gonadal dysgenesis (24%) was the leading cause, followed by Mayer Rokitansky Küster Hauser syndrome (21.9%).
• Other significant causes included constitutional delay, Turner syndrome, imperforate hymen, and vaginal septum.
• Endometrial receptor deficiency, hypogonadotropic hypogonadism, hypothyroidism, and congenital adrenal hyperplasia were also identified.

Conclusions:

• Gonadal dysgenesis is more prevalent than Mullerian duct abnormalities in primary amenorrhea.
• Endometrial receptor deficiency presents unique management challenges.
• Primary amenorrhea requires accurate diagnosis and management to alleviate patient and parental distress.