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Updated: Jan 27, 2026
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
Exosomal miRNA423-5p mediated oncogene activity in papillary thyroid carcinoma: a potential diagnostic and biological
1Department of General Surgery, Center of Thyroid and Parathyroid, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
Exosomes are considered important "messengers" between cells and their cargo, and some of the miRNAs composing their cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated in gastric cancer and associated with its poor prognosis. However, the role of exosome-derived miRNAs in papillary thyroid cancer (PTC) is still unclear and needs further study. In our work, we found that the level of Ex-miRNA423-5p was significantly increased in the serum of PTC patients compared with the serum of normal healthy people, and in vitro, we demonstrated that miRNA423-5p entered thyroid cancer cells through exosomes from thyroid cancer cell supernatant. Functional experiments demonstrated that overexpression of miRNA423-5p mimics in exosomes increased PTC cell migration and invasion, while the silencing of miRNA423-5p in TPC-1 cell exosomes inhibited PTC cell migration and invasion in vitro. These findings indicate that Ex- miRNA423-5p might serve as a potential tumor marker; thus, silencing miRNA423-5p in exosomes might represent a potential approach against PTC.
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